Well, what will they think of next? A little while ago, I wrote about the possibilities of using DNA as information storage. Researchers have now managed to insert a little movie into the genome of the E.coli bacterium (the workhorse of the genetics world). They used the CRISPR/Cas9 genome editing technique to insert the five frames of a galloping horse. Essentially, the snippets of DNA generated by CRISPR were used to correspond to pixels. Here’s the GIF:

galloping horse

Of course, you need to decode the message written in the nucleotides of the bacterial DNA to reconstruct the image (or movie), so you also have to have the ability to read it and know the code, and it’s incredibly laborious. You can’t just read it off one cell either, nor with one pass – it took several hundred thousand reads for the whole thing.

So why would you bother? Honestly, that’s a little ambiguous at the moment. Their original idea was to actually create a recording system to monitor changes happening in cells, in order, ultimately, to decipher how brain cells take on distinct identities. Instead of using indirect measurements or experimental perturbation to answer these questions, it would essentially get the cells to tell you what was happening to them themselves. They didn’t achieve that, but it’s a step towards it. Like many science advances, it’s an impressive technical feat that for now remains just a curio, but who knows where it may ultimately lead?

 

Reference

Shipman, S. L., et al.  Nature (2017). http://dx.doi.org/10.1038/nature23017

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